Reflections on Modeling Poliovirus Transmission and the Polio Eradication Endgame
نویسندگان
چکیده
منابع مشابه
Circulating Vaccine Derived Poliovirus and the polio eradication endgame
The world is now in the 24 year of the Global Polio Eradication Initiative. Halfway through that initiative in 2000, the island of Hispaniola saw an outbreak of vaccine derived poliovirus [1]. The implications of this outbreak and multiple subsequent isolations of Sabin strains that are estimated to have circulated in communities for a year or more are now causing a reconsideration of the optim...
متن کاملImpact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame
The polio eradication endgame aims to bring transmission of all polioviruses to a halt. To achieve this aim, it is essential to block viral replication in individuals via induction of a robust mucosal immune response. Although it has long been recognized that inactivated poliovirus vaccine (IPV) is incapable of inducing a strong mucosal response on its own, it has recently become clear that IPV...
متن کاملModeling poliovirus risks and the legacy of polio eradication.
This introduction to the special issue on modeling poliovirus risks provides context about historical efforts to manage polioviruses and reviews the insights from models developed to support risk management and policy development. Following an overview of the contents of the special issue, the introduction explores the road ahead and offers perspective on the legacy of polio eradication.
متن کاملPreventing Vaccine-Derived Poliovirus Emergence during the Polio Endgame
Reversion and spread of vaccine-derived poliovirus (VDPV) to cause outbreaks of poliomyelitis is a rare outcome resulting from immunisation with the live-attenuated oral poliovirus vaccines (OPVs). Global withdrawal of all three OPV serotypes is therefore a key objective of the polio endgame strategic plan, starting with serotype 2 (OPV2) in April 2016. Supplementary immunisation activities (SI...
متن کاملWhat role for inactivated poliovirus vaccine in the eradication endgame?
The 15-decade drive to control and eradicate polio through immunization [1] has benefited from the availability of 2 excellent vaccines, the inactivated poliovirus vaccine (IPV) of Salk and colleagues, licensed in 1955, and the live attenuated oral poliovirus vaccine (OPV) of Sabin, licensed in 1961. The 2 vaccines have complementary advantages, and both have played—and continue to play—importa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Risk Analysis
سال: 2020
ISSN: 0272-4332,1539-6924
DOI: 10.1111/risa.13484